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Ranjana Poddar and Surojit Paul Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine-NMDA receptor-mediated neuronal cell death Journal of Neurochemistry 124

Article first published online: 26 DEC 2012 | DOI: 10.1111/jnc.12102

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Hyperhomocysteinemia is an independent risk factor for neurological disorders. We report here that homocysteine-NMDA receptor mediated neuronal death involves a novel interplay between ERK and p38 MAPK where activation of p38 MAPK is downstream of and dependent on ERK MAPK. The direct regulatory role of ERK MAPK in p38 MAPK activation reveals a previously unidentified cellular mechanism for neuronal cell death.

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