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Ujval Anilkumar, Petronela Weisová, Heiko Düssmann, Caoimhín G. Concannon, Hans-Georg König and Jochen H. M. Prehn AMP-activated protein kinase (AMPK)–induced preconditioning in primary cortical neurons involves activation of MCL-1 Journal of Neurochemistry 124

Article first published online: 26 DEC 2012 | DOI: 10.1111/jnc.12108

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MCL-1 comes to the rescue: AMP-activated protein kinase (AMPK) is an ancient energy sensor that mediates the beneficial effects of ischemic pre-conditioning. This study identifies the anti-apoptotic, mitochondrial protein, MCL-1 as a key effector of AMPK-mediated preconditioning in neurons, and demonstrates that MCL-1 not only controls the level of apoptosis, but also acutely regulates neuronal Ca2+ homoestasis.

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