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Han-Gyu Kim, Choong-Ku Lee, Sung-Min Cho, Kum Whang, Byong-Ho Cha, Ju-Hyun Shin, Ki-Hak Song and Seong-Woo Jeong Neuregulin 1 up-regulates the expression of nicotinic acetylcholine receptors through the ErbB2/ErbB3-PI3K-MAPK signaling cascade in adult autonomic ganglion neurons Journal of Neurochemistry 124

Article first published online: 26 DEC 2012 | DOI: 10.1111/jnc.12109

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Neuregulin 1 (NRG1) is critical for formation of the autonomic nicotinic synapseduring development. However, the functional role of NRG1 in adult autonomic neurons remains unknown. We found NRG1-mediated up-regulation of the nicotinic acetylcholine receptor via the ErbB2/ErbB3-PI3K-MAPK signaling in MPG neurons of adult rat. This finding suggests that NRG1 is also required for maintenance of adult autonomic nicotinic synapse.

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