Jiwon Yang, Hye-na Ahn, Minsun Chang, Purnima Narasimhan, Pak H. Chan and Yun Seon Song Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice Journal of Neurochemistry 124
Our result showed that complement component 3 (C3) activation was down-regulated by antioxidant after cerebral ischemia, and was neuroprotective in mice model. Oxidative stress was highly related to C3activation after stroke, and C3 knock-down reduced ROS in primary neurons after hypoxia. An antioxidant that is able to inhibit C3 may offer the new strategy for therapeutic approaches in stroke.
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