Belén Goitia, Mariana Raineri, Laura E. González, José L. Rozas, Edgar Garcia-Rill, Verónica Bisagno and Francisco J. Urbano Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei Journal of Neurochemistry 124
Goitia et al. results support the hypothesis of a cocaine-mediated over-stimulation of presynaptic GABA release, altering TRN inter-somatic inhibition and increasing postsynaptic T-type calcium currents on VB neurons. Methylphenidate induced steady-state presynaptic inhibition of GABAergic terminals from TRN. Differences between methylphenidate and cocaine in sensory thalamic nuclei might have a correlation with changes in intracellular calcium concentrations.
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