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Mariana Angoa-Pérez, Michael J. Kane, Denise I. Briggs, Dina M. Francescutti, Catherine E. Sykes, Mrudang M. Shah, David M. Thomas and Donald M. Kuhn Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA Journal of Neurochemistry 125

Article first published online: 8 JAN 2013 | DOI: 10.1111/jnc.12114

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Mephedrone is a psychoactive component of ‘bath salts’. Despite its remarkable structural similarity to the neurotoxic amphetamines, mephedrone is not neurotoxic. Mephedrone is often co-abused with amphetamines, and data presented here show that when combined with methamphetamine, amphetamine, or MDMA, mephedrone significantly increases the neurotoxicity of the latter drugs. These findings focus much needed attention on the dangers associated with this designer drug of abuse.

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