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Tomohiro Nakanishi, Masamitsu Shimazawa, Sou Sugitani, Takashi Kudo, Shunsuke Imai, Yuta Inokuchi, Kazuhiro Tsuruma and Hideaki Hara Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice Journal of Neurochemistry 125

Version of Record online: 7 JAN 2013 | DOI: 10.1111/jnc.12116

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In the present study, excessive visible light exposure induced nitric oxide (NO) production, protein aggregation such as S-opsin in endoplasmic reticulum (ER), and expressions of bip and C/EBP-homologous protein (chop) mRNAs in photoreceptors. Knockdown of chop mRNA inhibited photoreceptor cell death induced by light exposure. Our findings suggest that ER stress plays a pivotal role in light-induced photoreceptor degeneration, and that this effect is mediated by CHOP. Therefore, the modulation of ER stress may be a potential therapeutic strategy for the treatment of retinal degenerative diseases.

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