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Stéphanie De Simoni, Dominique Linard, Emmanuel Hermans, Bernard Knoops and Julie Goemaere Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death Journal of Neurochemistry 125

Article first published online: 3 JAN 2013 | DOI: 10.1111/jnc.12117

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PRDX5 protects cells from oxidative stress by reducing peroxides and ONOO- in different subcellular compartments including mitochondria. Here we show that overexpression of mitochondrial PRDX5 prevents MPP+-induced dopaminergic neurodegeneration by inhibiting Ca2+ release from ER through IP3R thereby blocking subsequent apoptotic cascade. Our finding implies that PRDX5 may regulate redox modification of IP3R Ca2+ transporters via a crosstalk between mitochondria and ER.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12171.

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