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Mona Bains, John E. Cebak, Lesley K. Gilmer, Colleen C. Barnes, Stephanie N. Thompson, James W. Geddes and Edward D. Hall Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model Journal of Neurochemistry 125

Version of Record online: 28 JAN 2013 | DOI: 10.1111/jnc.12118

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This study details a dose-response and therapeutic window analysis of the brain and cell penetrable calpain inhibitor SNJ-1945 concerning its ability to reduce cortical cytoskeletal degradation when administered during the first minutes and hours after controlled cortical impact traumatic brain injury in the mouse. The compound produced a maximum 60% decrease in cytoskeletal damage when administered within the first hour after TBI, but lost its effect if treatment was delayed for 1 hour. These results fail to support the clinical practicality of direct calpain inhibition as a neuroprotective strategy.

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