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Alba González-Usano, Omar Cauli, Ana Agustí and Vicente Felipo Hyperammonemia alters the modulation by different neurosteroids of the glutamate–nitric oxide–cyclic GMP pathway through NMDA- GABAA- or sigma receptors in cerebellum in vivo Journal of Neurochemistry 125

Version of Record online: 17 FEB 2013 | DOI: 10.1111/jnc.12119

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Several neurosteroids modulate the glutamate–nitric oxide–cGMP pathway in cerebellum through modulation of NMDA- GABAA- or sigma receptors. Hyperammonemia alters neurosteroids' concentrations and impair this pathway, leading to cognitive impairment. We show, by in vivo brain microdialysis, that hyperammonemia modifies the type of effects of pregnanolone and pregnenolone (in red) and potentiates other neurosteroids' effects. This may contribute to cognitive impairment.

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