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Kazuhide Hayakawa, Nobukazu Miyamoto, Ji Hae Seo, Loc-Duyen D. Pham, Kyu-Won Kim, Eng H. Lo and Ken Arai High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter Journal of Neurochemistry 125

Version of Record online: 28 DEC 2012 | DOI: 10.1111/jnc.12120

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Beyond cell-cell signaling within the brain, crosstalk between brain and blood cells is now proposed as an important facet for brain recovery. In this study, we demonstrate that astrocyte-derived HMGB1 is an important mediator for attracting circulating endothelial progenitor cells (EPSc) into damaged white matter. Our findings may provide an important mechanism for the dynamic crosstalk between brain and circulating blood cells.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12174.

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