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Petra Popovics, Alexander Gray, Mohammed Arastoo, Deana K. Finelli, Audrey J. L. Tan and Alan J. Stewart Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth Journal of Neurochemistry 124

Version of Record online: 8 JAN 2013 | DOI: 10.1111/jnc.12122

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PLCη2 is a Ca2+-responsive phospholipase C implicated in the regulation of neuronal differentiation/maturation. Targeted knockdown of PLCη2 expression in retinoic acid-stimulated Neuro2A cells impacted upon neurite growth, RARE activation and LIMK1/CREB signaling. The PLCη2 PH domain was also found to possess a high affinity toward PtdIns(3,4,5)P3, suggesting this phospholipid to be important for the spatial control of PLCη2 signaling.

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