Jens Baron, Christian Blex, Astrid Rohrbeck, Sivarama Krishna Rachakonda, Lutz Birnbaumer, Gudrun Ahnert-Hilger and Irene Brunk The α-subunit of the trimeric GTPase Go2 regulates axonal growth Journal of Neurochemistry 124
Go1α is known to be involved in axonal growth, whereas Go2α had not been investigated in this respect so far. Active Go2α interacts with Rap1GAP. Cerebral Rap1GTP levels and axonal growth and branching are enhanced in Go2α−/− mice, when compared with wild-type mice. Go2α regulates axonal growth, most likely via Rap1GAP and Rap1.
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