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Emmy H. Rannikko, Louise Buur Vesterager, Jafar H. A. Shaik, Stephanie S. Weber, Elena M. Cornejo Castro, Karina Fog, Poul H. Jensen and Philipp J. Kahle Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion Journal of Neurochemistry 125

Article first published online: 15 JAN 2013 | DOI: 10.1111/jnc.12126

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DJ-1wt inhibits ASK1 activation by preferably binding to its N-terminal domain in presence of oxidative stress. The unstable and dimerization-defective DJ-1P158Δ mutant interacts with ASK1 also under normal conditions; the binding site may differ from the one for the wild-type. This leads to decreased inhibition of ASK1 activation and hence decreased cytoprotection.

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