E-mail a Wiley Online Library Link

Misha Zilberter, Anton Ivanov, Sofya Ziyatdinova, Marat Mukhtarov, Anton Malkov, Alan Alpár, Giuseppe Tortoriello, Catherine H. Botting, Lívia Fülöp, Alex A. Osypov, Asla Pitkänen, Heikki Tanila, Tibor Harkany and Yuri Zilberter Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease Journal of Neurochemistry 125

Article first published online: 10 JAN 2013 | DOI: 10.1111/jnc.12127

Thumbnail image of graphical abstract

When Alzheimer's disease is diagnosed, it is too late for any known treatment. Earlier stages are characterized by metabolic crisis and neuronal hyperactivity leading to increased energy demands, thus creating a vicious circle. We show that dietary supplementation with natural energy substrates in Alzheimer's mice model breaks this vicious circle reversing epileptogenesis in vivo and correcting neuronal pathologies ex vivo/in vitro.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12138.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.