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Monica S. Guzman, Xavier De Jaeger, Maria Drangova, Marco A. M. Prado, Robert Gros and Vania F. Prado Mice with selective elimination of striatal acetylcholine release are lean, show altered energy homeostasis and changed sleep/wake cycle Journal of Neurochemistry 124

Version of Record online: 15 JAN 2013 | DOI: 10.1111/jnc.12128

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Mice with ablation of the vesicular acetylcholine transporter in the striatum are lean because of changes in metabolism. Mutant mice show higher levels of insulin and spend less time sleeping. These results show that striatal acetylcholine is important for the modulation of energy expenditure and sleep regulation. These findings open new targets for the treatment of obesity and metabolic syndrome.

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