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Sarah E. Latchney, Amy M. Hein, M. Kerry O'Banion, Emanuel DiCicco-Bloom and Lisa A. Opanashuk Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory Journal of Neurochemistry 125

Article first published online: 7 JAN 2013 | DOI: 10.1111/jnc.12130

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The environmental toxicant dioxin is linked to cognitive dysfunction and acts via AhR, which serves multiple developmental roles. Here, we show that adult hippocampal neural precursors express AhR mRNA, and that both receptor deletion and dioxin activation compromise hippocampal-dependent memory and neurogenesis. Our findings suggest that AhR normally participates in regulating hippocampal neurogenesis, and that human dioxin exposure may impact cognitive performance.

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