Sebok Kumar Halder, Hayato Matsunaga, Haruka Yamaguchi and Hiroshi Ueda Novel neuroprotective action of prothymosin alpha-derived peptide against retinal and brain ischemic damages Journal of Neurochemistry 125
This study aimed at identifying the neuroprotective domain in ProTα against ischemic stress in vitro and in vivo. The novel finding is that active peptide sequence P30 (a.a. 49–78) of ProTα ameliorates ischemia-induced cellular and functional damages. The detailed mechanisms of P30-induced neuroprotection may provide a novel solution for treatment of ischemic damages.
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