E-mail

E-mail a Wiley Online Library Link

Hadhemi Kaddour, Yosra Hamdi, David Vaudry, Magalie Basille, Laurence Desrues, Jérôme Leprince, Hélène Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri and Olfa Masmoudi-Kouki The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway Journal of Neurochemistry 125

Article first published online: 19 FEB 2013 | DOI: 10.1111/jnc.12140

Thumbnail image of graphical abstract

We proposed the following cascade for the neuroprotective effect of octadecaneuropeptide (ODN) against 6-OHDA-induced neuronal death: ODN provokes a stimulation of ERK phosphorylation, through a PKC-dependent mechanism. Activation of ERK counteracts the inhibition of Bcl-2 and the stimulation of the pro-apoptotic gene Bax induced by reactive oxygen species (ROS) formation and glutathione (GSH) depletion. These data may allow the development of new strategies for cerebral injury treatment.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH