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Zhiyuan Ma, Mary Rudacille, Howard M. Prentice and Rui Tao Characterization of electroencephalographic and biochemical responses at 5-HT promoting drug-induced onset of serotonin syndrome in rats Journal of Neurochemistry 125

Article first published online: 28 JAN 2013 | DOI: 10.1111/jnc.12141

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Serotonin (5HT) is known to improve mood, however, only when the levels of its release are in an appropriate range. Excessive 5HT is harmful, likely resulting in serotonin syndrome. The present study was to characterize the syndrome, suggesting that the syndrome onset can be revealed with EEG, measurements of tremor activity and changes of unbound 5HT concentration in the plasma.

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