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Chiara Cervetto, Susanna Alloisio, Daniela Frattaroli, Maria Chiara Mazzotta, Marco Milanese, Paola Gavazzo, Mario Passalacqua, Mario Nobile, Guido Maura and Manuela Marcoli The P2X7 receptor as a route for non-exocytotic glutamate release: dependence on the carboxyl tail Journal of Neurochemistry 124

Article first published online: 3 FEB 2013 | DOI: 10.1111/jnc.12143

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P2X7 receptors as a route for non-exocytotic glutamate efflux

P2X7 receptors trigger Ca2+-dependent exocytotic glutamate release, but also function as a route for non-exocytotic glutamate release. The P2X7 receptor's function for non-exocytotic glutamate efflux was dependent on the receptor C-tail and involved the juxtamembrane cysteine-rich motif of the tail. The finding should be relevant to understand the impact of naturally occurring P2X7 variants on glutamatergic transmission in health and disease.

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