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Kathleen M. Schoch, Catherine R. von Reyn, Jifeng Bian, Glenn C. Telling, David F. Meaney and Kathryn E. Saatman Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse Journal of Neurochemistry 125

Article first published online: 3 FEB 2013 | DOI: 10.1111/jnc.12144

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Brain injury-induced proteolysis is reduced in a novel calpastatin overexpressing transgenic mouse

Following brain injury, the activation of calpain proteases results in protein cleavage and eventual cell death. Calpain inhibition via calpastatin is an advantageous approach due to its highly specific interaction with calpains. Augmenting calpastatin levels in a novel transgenic mouse resulted in decreased breakdown of selected proteins, thereby identifying a potential therapeutic agent for both brain injury and neurodegenerative disorders.

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