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Ki Chan Kim, Pitna Kim, Hyo Sang Go, Chang Soon Choi, Jin Hee Park, Hee Jin Kim, Se Jin Jeon, Ike Campomayor dela Pena, Seol-Heui Han, Jae Hoon Cheong, Jong Hoon Ryu and Chan Young Shin Male-specific alteration in excitatory post-synaptic development and social interaction in pre-natal valproic acid exposure model of autism spectrum disorder Journal of Neurochemistry 124

Version of Record online: 3 FEB 2013 | DOI: 10.1111/jnc.12147

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Prenatal VPA exposure induces male inclined autistic symptoms including impaired social interactions and seizure susceptibility in rat fetus. These gender-specific impairments of VPA-exposed rats, which are similar to human autistic patients, may provide experimental models to elucidate the gender-dependent symptoms and molecular mechanisms in anti-social disorders including ASD, especially focusing on the development of excitatory/inhibitory nervous systems and synapses.

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