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Keita Sasaki, Tatsuro Yamasaki, Idowu O. Omotuyi, Masayoshi Mishina and Hiroshi Ueda Age-dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole Journal of Neurochemistry 124

Article first published online: 19 FEB 2013 | DOI: 10.1111/jnc.12149

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Gγ7 KO mice exhibited age-dependent motor dysfunction such as clasping reflex and motor incoordination without a significant loss of striatal projection neurons. The behavioral dyskinesia in Gγ7 KO mice was reversed during chronic administration of the D2R agonist pramipexole.

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