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Qian Wang and Matthew D. Whim Stress-induced changes in adrenal neuropeptide Y expression are regulated by a negative feedback loop Journal of Neurochemistry 125

Version of Record online: 17 FEB 2013 | DOI: 10.1111/jnc.12150

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Acute stress alters adrenal neuropeptide Y expression via a negative feedback loop

Stress increases the expression of the neuromodulator NPY in the adrenal medulla but the pathways mediating this effect are not clear. We find that under basal (stress-free) conditions, a negative feedback loop involving NPY release and the activation of Y2 receptors tonically inhibits adrenal NPY expression. Because stress overrides this inhibitory effect it may provide an efficient way to ensure the adrenal levels of NPY do not decline after intense sympathetic activity.

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