Andrej Tillinger, Regina Nostramo, Richard Kvetnansky, Lidia Serova and Esther L. Sabban Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids Journal of Neurochemistry 125
We found that gene expression of urocortin 2 (Ucn2) is not only the most abundant of CRH family members in adrenal medulla but also that stress triggers an enormous induction of Ucn2 mRNA levels. The stress-triggered release of CRH and rise of glucocorticoids is important for Ucn2 gene expression. Elevated Ucn2 can modulate adrenomedullary function in autocrine/paracrine fashion, with possible endocrine effect.
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