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Vasken L. Keleshian, Hiren R. Modi, Stanley I. Rapoport and Jagadeesh S. Rao Retracted: Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex Journal of Neurochemistry 125

Version of Record online: 17 FEB 2013 | DOI: 10.1111/jnc.12153

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Brain aging involves balance between protective and progressive factors. Increased expression of iPLA2 and cytochrome p450 epoxygenase and their products are neuroprotective. At the same time, increased neuroinflammatory markers and altered pro and anti-apoptotic factors could contribute to loss of synaptic proteins. This may lead to altered synaptic plasticity. These molecular alterations are influenced by gene specific epigenetic modifications.

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