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Cristina Lanni, Daniela Necchi, Antonella Pinto, Erica Buoso, Laura Buizza, Maurizio Memo, Daniela Uberti, Stefano Govoni and Marco Racchi Zyxin is a novel target for beta-amyloid peptide: characterization of its role in Alzheimer's pathogenesis Journal of Neurochemistry 125

Version of Record online: 13 FEB 2013 | DOI: 10.1111/jnc.12154

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Putative role of zyxin in Alzheimer pathogenesis Soluble Aβ modulates zyxin protein levels, fundamental in maintaining HIPK2 stability and p53 activity. When zyxin is down-regulated by Aβ peptides, HIPK2 activity is inhibited, thus inducing an altered conformational state of p53. These results may help the studies on Alzheimer pathogenesis, through the fine dissection of events related to Aβ activities.

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