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Yancy Ferrer-Acosta, Eva N. Rodríguez-Cruz, François Orange, Hector De Jesús-Cortés, Bismark Madera, Jaime Vaquer-Alicea, Juan Ballester, Maxime J.-F. Guinel, George S. Bloom and Irving E. Vega EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease Journal of Neurochemistry 125

Article first published online: 14 FEB 2013 | DOI: 10.1111/jnc.12155

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The calcium binding protein EFhd2 is a novel amyloid protein that co-aggregates with pathological tau proteins in Alzheimer's disease. EFhd2 is overexpressed in Alzheimer's disease brain and its coiled-coil domain mediates the association with tau proteins. The formation of EFhd2 oligomers may contribute to the aggregation of tau proteins, to either promote neuronal death or survival. This study further demonstrates that EFhd2 is a molecular factor involved in the pathobiology of tauopathies.

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