Maryam S. Vasefi, Jeff S. Kruk, John J. Heikkila and Michael A. Beazely 5-Hydroxytryptamine type 7 receptor neuroprotection against NMDA-induced excitotoxicity is PDGFβ receptor dependent Journal of Neurochemistry 125
Growth factor receptors in the CNS are protective against several neuronal insults. However, it is difficult to introduce growth factors into the brain because of their large size. We identify a pathway whereby serotonin (5-HT) 7 receptor agonists (small organic molecules) increase the expression of the platelet-derived growth factor (PDGF) receptor to protect neurons against toxicity.
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