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Maryam S. Vasefi, Jeff S. Kruk, John J. Heikkila and Michael A. Beazely 5-Hydroxytryptamine type 7 receptor neuroprotection against NMDA-induced excitotoxicity is PDGFβ receptor dependent Journal of Neurochemistry 125

Article first published online: 13 FEB 2013 | DOI: 10.1111/jnc.12157

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Growth factor receptors in the CNS are protective against several neuronal insults. However, it is difficult to introduce growth factors into the brain because of their large size. We identify a pathway whereby serotonin (5-HT) 7 receptor agonists (small organic molecules) increase the expression of the platelet-derived growth factor (PDGF) receptor to protect neurons against toxicity.

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