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Asha Bayliss, Giuliana Roselli and Peter D. Evans A comparison of the signalling properties of two tyramine receptors from Drosophila Journal of Neurochemistry 125

Version of Record online: 14 FEB 2013 | DOI: 10.1111/jnc.12158

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In invertebrates, the phenolamines, tyramine and octopamine, mediate roles usually associated with the vertebrate catecholamines, noradrenaline and adrenaline. Drosophila melanogaster expresses two closely structurally related putative tyramine-activated GPCRs (CG7431, CG16766). We show that the two receptors have different pharmacological signalling and internalization properties. CG16766 orthologues only occur in Drosophila species, whereas CG7431 orthologues also occur in other insect species.

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