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Nicolás Fuenzalida-Uribe, Rodrigo C. Meza, Hernán A. Hoffmann, Rodrigo Varas and Jorge M. Campusano nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster Journal of Neurochemistry 125

Version of Record online: 4 MAR 2013 | DOI: 10.1111/jnc.12161

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Octopamine (Oct) is a biogenic amine that plays a central role in the generation of behaviors in invertebrates. Using a new Drosophila brain preparation we show that α-bungarotoxin-sensitive nAChRs induce a fast, transient, dose-dependent efflux of endogenous Oct. We further show that the nAChR-induced Oct release is involved in the nicotine impairment of a mechanically-induced startle response.

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