Christian Pifl, Oleh Hornykiewicz, Javier Blesa, Rebeca Adánez, Carmen Cavada and José A. Obeso Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of Parkinsonism Journal of Neurochemistry 125
Parkinson patients and animals with experimentally reduced thalamic noradrenaline exhibit pathological thalamic discharge patterns. In Parkinson's disease, motor thalamic noradrenaline is profoundly reduced. MPTP-induced parkinsonian monkeys had in addition to basal ganglia dopamine loss noradrenaline losses specifically in the motor thalamus, with the ventroanterior motor nucleus being affected only in severe parkinsonism. Thus, noradrenaline, specifically in the thalamus, appears to be an important player in the pathophysiology of Parkinson's disease.
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