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In Ae Chang, Ku-Birm Kwon, Yang-Chun Park and Uk Namgung Permissive role of Cdc2 activity induced from astrocytes in neurite outgrowth Journal of Neurochemistry 125

Version of Record online: 13 FEB 2013 | DOI: 10.1111/jnc.12163

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We found that Cdc2 was strongly induced from reactive astrocytes after spinal cord injury. In long-term cultured astrocytes, Cdc2 phosphorylation of vimentin and activation of β3 integrin were associated with enhanced neurite outgrowth of co-cultured neurons. Our results suggest that astrocytes may attain permissiveness for regenerative responses via Cdc2 pathway activation.

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