In Ae Chang, Ku-Birm Kwon, Yang-Chun Park and Uk Namgung Permissive role of Cdc2 activity induced from astrocytes in neurite outgrowth Journal of Neurochemistry 125
We found that Cdc2 was strongly induced from reactive astrocytes after spinal cord injury. In long-term cultured astrocytes, Cdc2 phosphorylation of vimentin and activation of β3 integrin were associated with enhanced neurite outgrowth of co-cultured neurons. Our results suggest that astrocytes may attain permissiveness for regenerative responses via Cdc2 pathway activation.
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