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Mauro DiNuzzo, Federico Giove, Bruno Maraviglia and Silvia Mangia Glucose metabolism down-regulates the uptake of 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (6-NBDG) mediated by glucose transporter 1 isoform (GLUT1): theory and simulations using the symmetric four-state carrier model Journal of Neurochemistry 125

Version of Record online: 27 FEB 2013 | DOI: 10.1111/jnc.12164

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In this study, we used the four-state carrier model for brain GLUT1 to examine whether cellular glucose metabolism can be inferred from the accumulation of the fluorescent glucose analogue 6-NBDG, which is increasingly employed for indirect determination of glucose transport and utilization in neurons and astrocytes. However, our findings show that the relation between 6-NBDG uptake and glucose transport and utilization configures antiport not symport of the two substrates.

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