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Peter Hahl, Taron Davis, Cecilia Washburn, Jack T. Rogers and Ann Smith Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states Journal of Neurochemistry 125

Version of Record online: 25 FEB 2013 | DOI: 10.1111/jnc.12165

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Hemopexin helps protect the brain against heme toxicity from blood released in hemorrhage, ischemia, and stroke. Human neuron models have demonstrated that the hemopexin heme transport system is likely to be an important aspect of heme-iron detoxification, even in inflammatory conditions associated with traumatic injury or the development of neuro-degenerative diseases such as Alzheimer's Disease. Hemopexin provides safe heme sequestration and delivery for breakdown followed by heme oxygenase-1 and amyloid precursor protein induction. This research provides novel mechanistic insights into how hemopexin safely controls brain heme and iron levels, and should help develop therapies to treat diseases in which abnormal metal handling and oxidative stress are implicated in the pathogenesis.

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