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Nancy F. Cruz, Kelly K. Ball, Stanley C. Froehner, Marvin E. Adams and Gerald A. Dienel Regional registration of [6-14C]glucose metabolism during brain activation of α-syntrophin knockout mice Journal of Neurochemistry 125

Version of Record online: 6 MAR 2013 | DOI: 10.1111/jnc.12166

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Substantial lactate release from activated brain contradicts the notion that lactate shuttling provides major fuel. α-Syntrophin knockout mice were used to determine whether loss of the polarized localization of aquaporin4 (AQP4) at astrocytic endfeet influences lactate washout during sensory stimulation. Autoradiographic assays revealed greater retention of [14C]glucose metabolites in brain, suggesting that endfoot water fluxes contribute to metabolite washout via perivascular-lymphatic drainage.

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