Junhua Xiao, Richard A. Hughes, Joe Y. Lim, Agnes W. Wong, Jason J. Ivanusic, Anita H. Ferner, Trevor J. Kilpatrick and Simon S. Murray A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination Journal of Neurochemistry 125
The neurotrophin BDNF promotes peripheral myelination via the neurotrophin receptor p75NTR. To selectively target p75NTR, we have generated a small peptide (cyclo-dPAKKR) that structurally mimics the region of BDNF that binds p75NTR. Here we have demonstrated that cyclo-dPAKKR promotes peripheral myelination in vitro and in vivo, suggesting that selective targeting p75NTR, via cyclo-dPAKKR, is a strategy worthy of further investigation for the treatment of peripheral demyelinating diseases.
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