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Ryan Kochanski, Changya Peng, Tetsuhiro Higashida, Xiaokun Geng, Maik Hüttemann, Murali Guthikonda and Yuchuan Ding Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation Journal of Neurochemistry 126

Version of Record online: 24 FEB 2013 | DOI: 10.1111/jnc.12169

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This study investigated the neuroprotective effect of acute ethanol therapy following ischemic stroke. During early reperfusion, there is a detrimental increase in glycolysis and NADPH oxidase (NOX) activity. We found that ethanol reduced hyperglycolysis and NOX activation during early reperfusion, which correlated with a reduction in infarct volume and improvement in functional outcome, suggesting ethanol's utility as a post-stroke therapy.

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