Ryan Kochanski, Changya Peng, Tetsuhiro Higashida, Xiaokun Geng, Maik Hüttemann, Murali Guthikonda and Yuchuan Ding Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation Journal of Neurochemistry 126
This study investigated the neuroprotective effect of acute ethanol therapy following ischemic stroke. During early reperfusion, there is a detrimental increase in glycolysis and NADPH oxidase (NOX) activity. We found that ethanol reduced hyperglycolysis and NOX activation during early reperfusion, which correlated with a reduction in infarct volume and improvement in functional outcome, suggesting ethanol's utility as a post-stroke therapy.
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