Ketki Tulpule, Michaela C. Hohnholt and Ralf Dringen Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons Journal of Neurochemistry 125
Cultured cerebellar granule neurons efficiently metabolize exogenously applied formaldehyde which results in cellular and extracellular accumulation of formate. Formaldehyde exposure accelerates glycolysis, possibly due to inhibition of cytochrome c oxidase of the mitochondrial respiration chain by cellular formate, and stimulates glutathione (GSH) export via the multidrug resistance protein (Mrp) 1. These alterations could play a role in formaldehyde-induced neurotoxicity.
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