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Ketki Tulpule, Michaela C. Hohnholt and Ralf Dringen Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons Journal of Neurochemistry 125

Version of Record online: 24 FEB 2013 | DOI: 10.1111/jnc.12170

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Cultured cerebellar granule neurons efficiently metabolize exogenously applied formaldehyde which results in cellular and extracellular accumulation of formate. Formaldehyde exposure accelerates glycolysis, possibly due to inhibition of cytochrome c oxidase of the mitochondrial respiration chain by cellular formate, and stimulates glutathione (GSH) export via the multidrug resistance protein (Mrp) 1. These alterations could play a role in formaldehyde-induced neurotoxicity.

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