Qiang Qiang, Hiroaki Adachi, Zhe Huang, Yue-Mei Jiang, Masahisa Katsuno, Makoto Minamiyama, Hideki Doi, Shinjiro Matsumoto, Naohide Kondo, Yu Miyazaki, Madoka Iida, Genki Tohnai and Gen Sobue Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease Journal of Neurochemistry 126
Article first published online: 27 FEB 2013 | DOI: 10.1111/jnc.12172
Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR) gene. Here, we report that genistein, an isoflavone found in soy, disrupts the interaction between AR and ARA70 and promotes the degradation of mutant AR and ameliorates behavioral abnormalities in SBMA transgenic mice.
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