E-mail

E-mail a Wiley Online Library Link

Somayeh Ahmadiantehrani and Dorit Ron Dopamine D2 receptor activation leads to an up-regulation of glial cell line–derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268 Journal of Neurochemistry 125

Version of Record online: 27 FEB 2013 | DOI: 10.1111/jnc.12178

Thumbnail image of graphical abstract

Glial cell line–derived neurotrophic factor (GDNF) is essential for the survival, development, and function of dopaminergic neurons. The mechanisms governing its expression are largely unknown. We found that dopamine, via a D2R-Gβγ-ERK1/2 pathway, up-regulates the Zif268 transcription factor, which directly associates with the GDNF promoter to drive GDNF expression. Our findings suggest that this pathway may be targeted for the treatment of Parkinson's disease and drug addiction, as well as the enhancement of learning and memory processes.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH