Somayeh Ahmadiantehrani and Dorit Ron Dopamine D2 receptor activation leads to an up-regulation of glial cell line–derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268 Journal of Neurochemistry 125
Glial cell line–derived neurotrophic factor (GDNF) is essential for the survival, development, and function of dopaminergic neurons. The mechanisms governing its expression are largely unknown. We found that dopamine, via a D2R-Gβγ-ERK1/2 pathway, up-regulates the Zif268 transcription factor, which directly associates with the GDNF promoter to drive GDNF expression. Our findings suggest that this pathway may be targeted for the treatment of Parkinson's disease and drug addiction, as well as the enhancement of learning and memory processes.
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