Tanuja Bordia, J. Michael McIntosh and Maryka Quik The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release Journal of Neurochemistry 125
l-dopa-induced dyskinesias are a debilitating side effect of Parkinson's disease therapy that may arise because of excessive dopaminergic activity. Our previous studies showed that nicotine treatment reduced dyskinesias in Parkinsonian animal models. This study suggests that nicotine improves dyskinesias by reducing nicotinic receptor expression and function, that is, dopamine release.
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