Reid H. J. Olsen, Lance A. Johnson, Damian G. Zuloaga, Charles L. Limoli and Jacob Raber Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria Journal of Neurochemistry 125
The role of reactive oxygen species and mitochondria in cognition of healthy individuals is relatively understudied. Adult mice over-expressing mitochondrial catalase (MCAT) show reduced measures of anxiety in the elevated zero maze (left) and enhanced hippocampus-dependent memory in the contextual fear conditioning test (right an water maze). Measures of oxidative stress did not differ between the groups. Thus, catalase over-expression might be sufficient to cause these effects.
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