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Rajesh Ponnusamy and Bernhard Lohkamp Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5 Journal of Neurochemistry 125

Version of Record online: 5 MAR 2013 | DOI: 10.1111/jnc.12188

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Insights into the oligomerization of CRMPs: Crystal structure of human collapsin response mediator protein 5.

Collapsin response mediator proteins (CRMPs) are cytosolic homo- and/or hetero-tetrameric phosphoproteins crucial for neuronal development and repair. We determined the crystal structure of human CRMP-5, revealing a homo-tetramer assembly similar to that of other CRMPs. Solution studies indicate that subunit interactions in CRMP-5 and CRMP-1 homo-tetramers are weaker compared with CRMP-2, and that divalent cations, Ca2+ and Mg2+, destabilize them further.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12224.

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