Sophie Martin, Latifa Zekri, Alexandra Metz, Tangui Maurice, Karim Chebli, Michel Vignes and Jamal Tazi Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons Journal of Neurochemistry 125
The RNA-binding protein G3BP (Ras-GAP SH3-domain-binding Protein) is an essential component of stress granules, characterized by arrested translation. We developed a knockout (KO) mouse showing a role for G3BP1 in synaptic conduction in the hippocampus and calcium homeostasis, and in motor coordination. These KO mice provide a good model for neurodegenerative diseases involving stress granules formation.
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