Jing Jin, Jennifer Albertz, Zhihong Guo, Qi Peng, Gay Rudow, Juan C. Troncoso, Christopher A. Ross and Wenzhen Duan Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease Journal of Neurochemistry 125
Huntington's disease (HD) is a devastating neurodegenerative disease that no cure is available. We found that PPARγ agonist rosiglitazone normalizes the levels of the Sirt6, restores the levels of BDNF and PGC-1α in HD models. The protective effects of rosiglitazone in HD mice suggest that targeting the PPAR-γ signaling pathway should be considered in developing HD therapy.
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