Julie Brossaud, Hélène Roumes, Marie-Pierre Moisan, Véronique Pallet, Anabelle Redonnet and Jean-Benoît Corcuff Retinoids and glucocorticoids target common genes in hippocampal HT22 cells Journal of Neurochemistry 125
To better understand the mechanisms occurring during brain aging we studied genes altered by retinoids and glucocorticoids signalling in a hippocampal cell line. An interesting, but not unique, level of interaction is the altered transcription and translation of receptors involved in these pathways. Retinoic acid receptor β (RARβ) and glucocorticoid receptor (GR) are regulated by their own and reciprocal ligands, generating intricate and intertwined feedback loops.
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