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Julie Brossaud, Hélène Roumes, Marie-Pierre Moisan, Véronique Pallet, Anabelle Redonnet and Jean-Benoît Corcuff Retinoids and glucocorticoids target common genes in hippocampal HT22 cells Journal of Neurochemistry 125

Article first published online: 6 MAR 2013 | DOI: 10.1111/jnc.12192

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To better understand the mechanisms occurring during brain aging we studied genes altered by retinoids and glucocorticoids signalling in a hippocampal cell line. An interesting, but not unique, level of interaction is the altered transcription and translation of receptors involved in these pathways. Retinoic acid receptor β (RARβ) and glucocorticoid receptor (GR) are regulated by their own and reciprocal ligands, generating intricate and intertwined feedback loops.

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