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Shinji Higashi, Tomohiro Kabuta, Yoshitaka Nagai, Yukihiro Tsuchiya, Haruhiko Akiyama and Keiji Wada TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress Journal of Neurochemistry 126

Version of Record online: 1 MAR 2013 | DOI: 10.1111/jnc.12194

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TDP-43 is an important contributor to ALS and FTLD. In this study, we revealed that TDP-43 associates with stalled ribosomes and that its silencing disturbs mRNA stability and cell survival during cellular stress. Our findings suggest that TDP-43 is a stress-response protein that functions in translational control mechanisms and determines cell survival.

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